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Chandrashekhar, V. M.
- Antidiarrhoeal Activity of Abutilon indicum Linn Leaf Extract
Authors
Source
Journal of Natural Remedies, Vol 4, No 1 (2004), Pagination: 12-16Abstract
Objective: The present study is aimed to evaluate the leaf extracts of Abutilon indicum for acclaimed anti-diarrhoeal activity using albino rats. Materials and methods: Anti-diarrhoeal activity of Abutilon indicum was evaluated by gastro intestinal motility, castor oil-induced diarrhoea and prostaglandin E2 -induced enteropooling in rats. Loperamide was used as a standard drug. Results : The study revealed that, the methanolic extract and aqueous extract possessed significant antidiarrhoeal activity in castor oil-induced diarrhoea and prostaglandin E2-induced diarrhoea, compared to the control group. Conclusion: Abutilon indicum showed significant anti-diarrhoeal activity as compared to loperamide and can be recommended for further studies.Keywords
Abutilon indicum, Loperamide, Antidiarrhoeal Activity, Albino Rats- Evaluation of Hepatoprotective and Antioxidant Activity of Stereospermum suaveolens Against Aluminium Fluoride Induced Hepatotoxicity
Authors
Source
Journal of Natural Remedies, Vol 11, No 2 (2011), Pagination: 143-149Abstract
To evaluate the hepatoprotective activity of methanol stem bark extract of Stereospermum suaveolens DC (Bignoniaceae) against aluminium fluoride (AlF4E)-induced hepatic damage in albino mice. The animals were divided into six groups of seven animals each. Group I served as normal; group II served as control, receives AlF4E through their drinking water; group III served as standard, receives 500 mg/kg of Liv-52. The groups IV, V and VI were treated with 125, 250 and 500 mg/kg doses of methanol extract of Stereospermum suaveolens orally. After the 24 h of the last dose of AlF4E, serum biochemical and liver enzymes were assessed along with histopathological studies of liver sections. The AlF4E-treated group showed a significant (p<0.05) increase in serum biochemical markers like SGOT, SGPT, ALP, total bilirubin, LDL-cholesterol and lipid peroxidation levels in liver homogenate along with significant reduced levels of GSH, total thiols, CAT and SOD. The pretreatment groups with different doses of extract and standard Liv-52 were significantly (p<0.05) reversed the above parameters as compared to control group. From the results it can be concluded that hepatoprotective and antioxidant activity of methanol extract may be due to presence of flavonoids and tannins.Keywords
Antioxidants, Free Radicals, Hepatoprotective, Stereospermum suaveolens- Protective Effect of Punica granatum L. on Gentamicin-Induced Acute Renal Failure in Adult Rats
Authors
1 H.S.K College of Pharmacy, Bagalkot-587101, Karnataka, IN
2 HIPER, Hamirpur, Himachal Pradesh, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 8, No 4 (2016), Pagination: 161-167Abstract
Aim: Study was undertaken to evaluate the effect of Punica granatum L.on Gentamicin-induced renal failure in rats.
Materials and methods: Gr.-I rats served as normal, received 0.5 ml of 5% Tween-80 in distilled water, Gr.-II was injected with Gentamicin (100 mg/kg, ip), Gr.-III was injected with Gentamicin and selenium (2 mg/kg, ip), and Gr.-IV-IX were given orally Punica granatum fruit chloroform extract (PGCE) and Punica granatum methanol extract (PGME) at the doses of 100, 200 and 400 mg/kg, respectively, were administered for eight days in Gentamicin-induced renal failure rats. On last day, Blood and 24 h urine was collected and used for estimation of serum and urine creatinine, urea, uric acid levels. The kidney homogenate was used for the estimation of LPO, SOD, CAT and GSH levels and Kidney sections were analyzed for histopathology.
Results: Gentamicin-induced (Gr.-II) had significant increase in levels of serum and urine creatinine, urea, uric acid, lipid peroxidation and significantly decrease in SOD, CAT and GSH levels as compared to normal (Gr.-I). The treatment of PGCE and PGME 100, 200 and 400 mg/kg doses (Gr. IV-IX), significantly decreases serum and urine creatinine, urea, uric acid and significantly increases SOD, CAT and GSH levels in kidney homogenate with significant decrease in lipid peroxidation as compared to Gr.-II.
Conclusions: The PGCE and PGME at the doses of 400 mg/kg, found to be more effective in protecting the Gentamicin-induced renal failure in rats.